Review, 2019: The microbiome, cancer, and cancer therapy https://www.nature.com/articles/s41591-019-0377-7
Review, 2019: The Gut Microbiota in Causation, Detection, and Treatment of Cancer https://journals.lww.com/ajg/Abstract/publishahead/The_Gut_Microbiota_in_Causation,_Detection,_and.99833.aspx
Review, 2019: Bugs, drugs, and cancer: can the microbiome be a potential therapeutic target for cancer management? https://doi.org/10.1016/j.drudis.2019.02.009 "Gut microbiomes play an important role influencing chemotherapeutic and immunotherapeutic outcomes. Bacteria-targeting intervention can be an effective strategy for improving cancer treatment."
Review, 2019: Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action https://doi.org/10.1080/10408398.2018.1555789
Review, 2018: Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy https://doi.org/10.3389/fmicb.2018.02020 "overview of how the bacterial signals and signatures may influence epithelial homeostasis and delineate mechanisms, which might be potential targets for therapy"
Review, 2018: Microbiota in cancer development and treatment https://link.springer.com/article/10.1007/s00432-018-2816-0 "In this review, the role of microbiota is explained in carcinogenesis, mechanisms of microbiota-mediated carcinogenesis, and role of gut microbiota in modulation of cancer therapy"
Researchers discover that a bacterial protein promotes cancer (Dec 2018, mice) https://medicalxpress.com/news/2018-12-bacterial-protein-cancer.html - Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties https://doi.org/10.1073/pnas.1815660115
A gut punch fights cancer and infection. Microorganisms in the human gut can affect immune-system cells. Gut bacterial strains have been discovered that boost immune cells that have cell-killing capacity and that can target cancer and protect against infection. (Jan 2019): https://www.nature.com/articles/d41586-019-00133-w
How a healthy microbiome could supercharge the body's natural cancer-fighting cells. Particular [gut] microbiota metabolites enhanced the ability of killer cells to survive & form memory cells. These SCFAs change the way that the killer utilize fuels for energy generation (Jul 2019, mice) https://newatlas.com/healthy-microbiome-natural-cancer-fighting-cells/60377/. Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.
A gut bacteria (e.coli) toxin (colibactin) that damages DNA may be involved in bowel cancer. https://www.newscientist.com/article/2193997-a-gut-bacteria-toxin-that-damages-dna-may-be-involved-in-bowel-cancer/. Revealing a microbial carcinogen (2019, in vitro, mice): http://science.sciencemag.org/content/363/6428/689
Interplay between viruses and bacterial microbiota in cancer development (2017): http://www.sciencedirect.com/science/article/pii/S1044532316300823 "healthy gut microbiota stimulates host immune system resulting in HBV infection clearance; sterilization of gut microbiota with antibiotics reduced the ability of adult mice to clear HBV infection"
Causal Link Between Anticancer Immunity and Gut Microbiome Identified https://www.genengnews.com/news/causal-link-between-anticancer-immunity-and-gut-microbiome-identified/. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice (April 2019): https://www.nature.com/articles/s41467-019-09525-y
New study finds Zika vaccine can treat brain tumors. The virus infection triggered a strong antiviral response, which elicited inflammation that killed GBM stem cells. Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143740/
Review, Mar 2019: Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored https://www.mdpi.com/2073-4409/8/4/293/htm
Review, April 2019: The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer https://www.sciencedirect.com/science/article/pii/S0304419X19300423 "In conclusion, breast harbors a community of microbes that can communicate with the host cells inducing downstream signaling pathways and modulating various aspects of breast cancer growth and metastatic progression and an improved understanding of microbial dysbiosis can potentially reduce breast cancer risk and improve outcomes of breast cancer patients"
Unhealthy gut promotes spread of breast cancer. (May 2019, mice) Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer https://medicalxpress.com/news/2019-06-unhealthy-gut-breast-cancer.html
Vaginal dysbiosis, and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis (Dec 2018). "This study supports a causal link between vaginal dysbiosis and cervical cancer" https://archive.fo/Ztvup
Relationship between the Cervical Microbiome, HIV Status, and Precancerous Lesions (Feb 2019): https://mbio.asm.org/content/10/1/e02785-18 "leads us to propose that Mycoplasma contributes to a cervical microbiome status that promotes HPV-related cervical lesions"
Review, 2019: Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-019-0621-2
Review, 2018: Colorectal carcinogenesis: an archetype of gut microbiota–host interaction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145524/
Review, 2018: Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer https://www.karger.com/Article/FullText/494052
Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer (Jul 2019) https://www.utsouthwestern.edu/newsroom/articles/year-2019/precision-editing-gut-bacteria.html "The most significant finding in this study is that manipulating the intestinal microbiome is sufficient to affect the development of tumors"
Single probiotic supplement (Lactobacillus helveticus NS8) suppresses colitis‐associated colorectal tumourigenesis by modulating inflammatory development and microbial homeostasis (mice, 2018): https://doi.org/10.1111/jgh.14516
Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model (June 2019) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216393 (Lactobacillus casei strain Shirota and Bifidobacterium breve strain Yakult + 4G-β-Galactosyl-sucrose). "Conversely, neither probiotics nor prebiotics had any effect on inflammation and tumorigenesis"
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin (2018): http://dx.doi.org/10.1136/gutjnl-2018-317200
Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice (2018): https://doi.org/10.1053/j.gastro.2018.12.003
In conclusion, this study suggests that local microbiome dysbiosis may contribute to functional changes at the cancer sites. Results from the current study also contributed to the list of metabolites that are found to differ between normal and tumor sites in CRC (2018): https://doi.org/10.1371/journal.pone.0208584 Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa.
How a common oral bacteria makes colon cancer more deadly. "We propose a two-hit model, where genetic mutations are the first hit. F. nucleatum serves as the second hit, accelerating the cancer signaling pathway and speeding tumor growth." (Mar 2019) https://www.eurekalert.org/pub_releases/2019-03/cuim-hac022719.php Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1 http://embor.embopress.org/content/early/2019/03/01/embr.201847638
Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer (Mar 2019): https://www.nature.com/articles/s41418-019-0312-y
Two meta-analysis of metagenomes papers discovering predictive and diagnostic markers for colorectal cancer (April 2019): https://www.nature.com/articles/s41591-019-0406-6 - https://www.nature.com/articles/s41591-019-0405-7
Review, 2018: Microbial community reshaped in gastric cancer https://www.europeanreview.org/article/16260 "Currently, it appears disrupted homeostasis and inter-individual variations of gastric microbiota are involved in cancer development"
Review, 2019: The Microbiome and Genitourinary Cancer: A Collaborative Review https://doi.org/10.1016/j.eururo.2018.12.043 "There is preliminary evidence to implicate the members of the genitourinary microbiota as causative factors or cofactors in genitourinary malignancy. Clinical trials, such as fecal microbiota transplant to increase the efficacy of immunotherapy, are currently underway"
Review, 2017: The gut microbiome and liver cancer: mechanisms and clinical translation: https://archive.fo/vmNXV
Bile Acids, the Microbiome, Immunity, and Liver Tumors (2018): https://www.nejm.org/doi/10.1056/NEJMcibr1807106 Bile acids affect the expression of a chemokine ligand by liver sinusoidal endothelial cells, which in turn affects the extent to which a type of natural killer cell is present in and diminishes the burden of hepatocellular carcinomas in a mouse model of the disease.
Study finds gut microbiome can control antitumor immune function in liver. "if you treat mice with antibiotics and thereby deplete certain bacteria, you can change the composition of immune cells of the liver [due to bile acid changes], affecting tumor growth in the liver" (2018): https://archive.fo/8RsAE
Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma (2019): https://doi.org/10.1186/s13099-018-0281-6
Circulating Microbiota-Based Metagenomic Signature for Detection of Hepatocellular Carcinoma (May 2019) https://www.nature.com/articles/s41598-019-44012-w "this model accurately distinguished HCC with an AUC of 0.875 and an accuracy of 79.8%"
Bacteria promote lung tumor development, study suggests. https://news.mit.edu/2019/bacteria-promote-lung-tumor-development-0131 Commensal Microbiota Promote Lung Cancer Development via γδ T Cells (Jan 2019). https://doi.org/10.1016/j.cell.2018.12.040 "were able to greatly reduce the number and size of the lung tumors by treating the mice with antibiotics or blocking the immune cells stimulated by the bacteria"
Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases (mice, 2018): https://doi.org/10.1016/j.celrep.2018.08.090 "Aerosolized Lactobacillus rhamnosus strongly promoted immunity against B16 lung metastases as well. Furthermore, probiotics or antibiotics improved chemotherapy activity against advanced B16 metastases"
Alterations of fecal bacterial communities in patients with lung cancer (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220220/ "To our knowledge, this is the first study to evaluate the correlations between certain specific bacteria and inflammatory indicators"
Review, Feb 2019: The microbiome and oral cancer: More questions than answers https://www.sciencedirect.com/science/article/abs/pii/S1368837518304597
"Our current theory is that your gut bacteria determine whether your oral bacteria cause cancer" (2017): https://www.irishtimes.com/news/science/bugging-cancer-gut-bacteria-and-the-big-c-1.3096035
Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus (2019): https://doi.org/10.1002/ijc.32152
Review, Feb 2019: The role of the microbiome in immunologic development and its implication for pancreatic cancer immunotherapy https://doi.org/10.1053/j.gastro.2018.12.045 "In this review, we highlight the essential role of the microbiome in immune system development and maturation. We review how microbe-induced immune activation promotes oncogenesis, focusing particularly on pancreatic carcinogenesis, and show that modulation of the microbiome augments the anti-cancer immune response and enables successful immunotherapy against pancreatic cancer"
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes (Aug 2019) https://www.mdanderson.org/newsroom/bacteria-on-tumors-influences-immune-response-and-survival-of-pa.h00-159305412.html "fecal microbiota transplants (FMT) from long-term survivors prompted immune response and stifled tumors in a mouse model of the disease by altering the bacteria on the tumor"
Gut bacteria determine speed of tumor growth in pancreatic cancer. The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells. (2018): https://archive.fo/Ml7dn
Tongue microbiome could help identify patients with early-stage pancreatic cancer (2019): https://www.eurekalert.org/pub_releases/2019-01/tfg-tmc012519.php - Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls: https://tandfonline.com/doi/full/10.1080/20002297.2018.1563409
Review, Mar 2019: The Human Microbiota and Prostate Cancer: Friend or Foe? https://www.mdpi.com/2072-6694/11/4/459/htm
Overuse of anti‐anaerobic drug is associated with poor post‐chemotherapy prognosis of patients with hepatocellular carcinoma (April 2019): https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32339
Review, June 2019: Antibiotics and immunotherapy in gastrointestinal tumors: Friend or foe? https://www.wjgnet.com/2307-8960/full/v7/i11/1253.htm "antibiotics may attenuate (weaken) the effect of immunotherapy"
Cancer is not directly caused by the bile, but by the dysbiosis the bile (secondary bile acids) causes: http://onlinelibrary.wiley.com/doi/10.1002/ijc.30643/abstract - Secondary bile acid‐induced dysbiosis promotes intestinal carcinogenesis (2017).
The study led by EMBL scientists focuses on a process in which certain gut bacteria turn bile acids that are part of our digestive juices into metabolites that can be carcinogenic (April 2019): https://medicalxpress.com/news/2019-04-global-microbial-signatures-colorectal-cancer.html - https://www.nature.com/articles/s41591-019-0406-6.
Review, Mar 2019: Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment https://www.mdpi.com/1010-660X/55/4/84
Gut microbiome affects efficacy of cancer drugs: http://www.nature.com/nrgastro/journal/vaop/ncurrent/full/nrgastro.2017.20.html - http://www.umassmed.edu/news/news-archives/2017/04/examining-the-role-of-the-microbiome-in-the-effectiveness-of-colorectal-cancer-treatment/
Researchers found certain bacteria hiding out among cancer cells, gobbling up chemotherapy drugs intended to demolish tumors. https://arstechnica.com/science/2017/09/see-jerkface-bacteria-hiding-in-tumors-and-gobbling-chemotherapy-drugs/
Chemotherapy-driven dysbiosis in the intestinal microbiome. (2015): https://www.ncbi.nlm.nih.gov/pubmed/26147207 - https://www.drperlmutter.com/chemotherapy-microbiome/
Fecal Microbiota Transplant:
Mayo Clinic study shows FMT is safe in cancer patients: https://www.youtube.com/watch?v=8_RWsL_2Foo
Fecal Transplant Heals Colitis [in 2 cancer patients] Caused by Immunotherapy (2018): https://www.the-scientist.com/news-opinion/fecal-transplant-heals-colitis-caused-by-immuno-65074
Replacing laboratory mice's gut microbiomes with the microbial communities of their wild counterparts alters the lab animals' immune systems and boosts their resistance to colorectal cancer development and influenza http://cancerdiscovery.aacrjournals.org/content/early/2017/11/14/2159-8290.CD-NB2017-162
Pancreatic cancer: "fecal microbiota transplants (FMT) from long-term survivors prompted immune response and stifled tumors in a mouse model of the disease by altering the bacteria on the tumor" (Aug 2019) https://www.mdanderson.org/newsroom/bacteria-on-tumors-influences-immune-response-and-survival-of-pa.h00-159305412.html
Review, 2018: Roles of intestinal microbiota in response to cancer immunotherapy https://doi.org/10.1007/s10096-018-3374-8
Review, 2018: The intimate relationship between gut microbiota and cancer immunotherapy https://doi.org/10.1080/19490976.2018.1527167
Review, Mar 2019: Importance of probiotics in the prevention and treatment of colorectal cancer https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.28473 "Research in clinical trials encouraging findings that support a role of probiotics in CRC prevention and improve the safety and effectiveness of cancer therapy even though additional clinical research is still necessary"