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Translocation

MaximilianKohler edited this page Sep 3, 2019 · 3 revisions

General:

Live commensal intestinal bacteria are present in the peripheral blood where they can induce inflammation. High rate of bacterial DNA in the blood samples indicates translocation in inflammatory bowel disease: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170034

Phage passing the gut barrier when bacteria can't: https://www.theatlantic.com/science/archive/2017/12/we-might-absorb-billions-of-viruses-every-day/547415/

"Bacteria can directly release factors into the systemic circulation or can translocate into blood" http://journals.sagepub.com/doi/10.1177/1535370217743766

Bacteria in the mouth can cause dementia via translocation to the blood stream: https://archive.fo/n4cQd

Phages can translocate through the mucosa to lymph and internal organs https://gutpathogens.biomedcentral.com/articles/10.1186/s13099-017-0196-7

Bacteria translocate into the blood in greater amount in ME, leading to inflammation (pg 10, Cornell) http://www.biochemistry.org/Portals/0/Biochemist/Apr17-compressedv2.pdf

Yale researchers describe research showing that harmful bacteria can make their way from the small intestines of mice to the lymph nodes, liver and spleen. Translocation of a gut pathobiont drives autoimmunity in mice and humans (2018): https://theoutline.com/post/3627/bad-gut-bacteria-can-spread-to-the-rest-of-your-body - http://science.sciencemag.org/content/359/6380/1156

in patients with PDA (pancreatic ductal adenocarcinoma), pathogenic gut bacteria migrate to the pancreas through the pancreatic duct (2018): https://medicalxpress.com/news/2018-03-gut-bacteria-tumor-growth-pancreatic.html

"They found both healthy and disease-causing bacteria moved freely between the bladder and the female reproductive tract, even in healthy women" (2018): http://www.abc.net.au/news/health/2018-06-03/bladder-microbiome-study-could-be-game-changer-for-uti-treatment/9822020 | and is similar to vaginal microbiome: https://medicalxpress.com/news/2018-06-bacteria-female-bladders.html

Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy (2018): https://www.nature.com/articles/s41598-018-26509-y

More of the Gut in the Lung: How Two Microbiomes Meet in ARDS (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020735/

"once phages successfully enter the body, they reach most organs, including the central nervous system" (review, Mar 2019): Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review https://onlinelibrary.wiley.com/doi/full/10.1002/med.21572

Blood microbiome:

Even under healthy conditions, human blood contains bacterial DNA capable of triggering host innate immune responses (Hacker et al. 2002; Muruve et al. 2008; Nikkari et al. 2001). https://link.springer.com/article/10.1007%2Fs11357-018-0026-y

Composition and richness of the serum microbiome differ by age and link to systemic inflammation (2018): https://link.springer.com/article/10.1007%2Fs11357-018-0026-y - "In the present study, the analysis performed from whole serum cannot differentiate between microbial DNA fragments and intact microbes."

Comprehensive description of blood microbiome from healthy donors assessed by 16S targeted metagenomic sequencing (2016): https://doi.org/10.1111/trf.13477

8/21/2017 Stanford study using shotgun sequencing says we still don't know 99% of human microbes: Humans are colonized by many uncharacterized and highly divergent microbes. "Through massive shotgun sequencing of circulating cell-free DNA from the blood, we identified hundreds of new bacteria and viruses which represent previously unidentified members of the human microbiome." https://doi.org/10.1073/pnas.1707009114

The dormant blood microbiome in chronic, inflammatory diseases (2015): https://doi.org/10.1093/femsre/fuv013

Circulating microbiome in blood of different circulatory compartments (2018): http://dx.doi.org/10.1136/gutjnl-2018-316227

Cultural Isolation and Characteristics of the Blood Microbiome of Healthy Individuals (2018): https://doi.org/10.4236/aim.2018.85027

Cerebrospinal Fluid:

The virome of cerebrospinal fluid: viruses where we once thought there were none (Sept 2019) https://www.frontiersin.org/articles/10.3389/fmicb.2019.02061/abstract "By identifying a virome in the CSF of mostly healthy individuals, it is now less likely that any human body site is devoid of microbes"

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