Transporters Question

[pdlj671]

Hi all,

I'm currently working on manually adding an active transporter to the placenta in the pregnancy model.

I looked through the MoBi documentation on adding the transporter, and wanted to confirm if this is what is happening while simultaneously building the pregnancy model.

1. I create a PK-Sim model with the 5-HT and the SERT transporter.
2. I send the simulation to MoBi and I can now access equations related to the SERT transporter.
3. I extended the model to a pregnancy PBPK model following the tutorial.

Since SERT was in the nonpregnant PBPK model, the equations related to SERT transporting 5-HT should also apply to the pregnancy compartments?

Based off the picture below, from what I understand is that the transport ActiveInfluxSpecificInterstitialToIntracellular_MM is transporting 5-HT from the interstitial space to intracellular space where the SERT transporter is expressed. Is that correct?

Then, if I wanted to only look at the transport within the placenta I would manually add that shown below.

Is this the correct way of understanding how transporters work in MoBi?