Request for Guidance and Documentation on Dermal PBPK Modeling Using PK-Sim

[pc5134]

We would like to ask whether you have any example projects, tutorial models, or guidance documents for topical formulations. In particular, we are interested in understanding:

1. How to build a dermal/topical formulation model from start to finish.
2. The purpose and selection of the various parameters used for topical simulations.
3. How to define the formulation, absorption model, and skin-related parameters.
4. Best practices for developing and validating dermal PBPK models in PK-Sim.
5. Any sample PK-Sim or MoBi project files that could help new users understand the workflow.

[github-actions[bot]]

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[tobiasK2001]

Hi,

please also check out this recent best practice paper https://doi.org/10.1002/psp4.70295.
It also points to other papers for dermal PBPK models.

best,Tobias