Food effect overestimated

[MSmodeler]

Dear all,

For my Finasteride PBPK model I have one plasma concentration study who have reported food intake in there study protocol. However after simulating the plasma concentration time curve simulated values are way underpricted. In another discussion #566 @PavelBal mentioned that the gastric emptying rate does not return to fasted state. Therefore I tried the proposed solution and set the stop condition to (StomachIntestinalTransitRate > 1/GET) OR (Time >= 1.5*60). regarding to this I got a question of the defintion of the parameter StomachIntestinalTransitRate. I know that GET refelcts the time where approximatly 63 % of the apllied dose is released from stomach to duodenum. In papers I only found values for the t1/2 values for gastric emptying time where half of the amount of the stomach has leaved the stomach https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1746.2006.04449.x. So I wanted to ask if this t1/2 value could be a valid parameter reflecting the 1/GET value or if I missunderstood the 1/GET value.

Thank you for help.