Version 12 Update 3 Hotfix 1

Downloads:

• Full setup

  MD5-Hash	SHA256-Hash
  99a1bca9f36d896e594d6759d24824c8	e910a46f76c852f9f5a021257c021a9e5c101934f722ef11cb9ff9eb10a939aa

  

• ospsuite R package

• Gene expression database (human)

  • Additional gene expression databases for human and animal species can be found here.

Portable versions of PK-Sim and MoBi

Portable versions provide an alternative way to use the tools if for some reason the full installation of the OSP software suite is not practical.
No installation is required: just download and extract the zip archives and run PKSim.exe or MoBi.exe from the extracted folder.

• Download PK-Sim 12.3 portable version
• Download MoBi 12.3 portable version

Notes for Portable Versions:

1. Portable versions do not affect the installed OSP Suite and do not interfere with each other.

2. If you only need one tool (e.g. only PK-Sim) - there is no need to download another portable tool(s).

3. PK-Sim and MoBi rely on some common Windows components: .NET Framework and C++ Runtime redistributable.
   In most cases these components are already installed on the target machine. In the very unlikely case that they aren't:

   • If PK-Sim (or MoBi) Portable crashes immediately on startup: The .NET Framework is missing. Download and install it from here.
   • If the program starts and you can create a simulation, but running a simulation crashes: The C++ Runtime is missing. Download and install it from here.

4. If you use the functionality "Send to MoBi" in PK-Sim: you have to enter the location of MoBi.exe (portable) in the program options (vice versa for MoBi).

5. When you double-click PK-Sim or MoBi project in Windows Explorer - it will always start the installed application (the one installed with the full OSP Suite setup), not one of the portables.

6. If you are using the OSP Qualification Runner (as part of the OSP Qualification Framework) - the path to the portable PK-Sim folder must be passed as an argument, otherwise the installed version will be used.

Release Notes for the Open Systems Pharmacology Software Suite 12 Update 3 Hotfix 1

Fixed issues and Improvements

PK-Sim

• Fixed incorrect updates of effective molecular weight during validation

OSP Platform qualification library and PBPK Models Library

Platform qualification library extended

New reports added:

• Pediatric Qualification Package: P-gp Ontogeny

New releases of OSP Platform qualification library and PBPK Models Library

As with every new OSP Suite release, ALL platform qualification reports and model evaluation reports have been recreated with the new version of the OSP Suite:

• OSP Qualification Reports library
  • See the Release Notes for a full list of changes.
• OSP-PBPK-Model-Library
  • See the Release Notes for a full list of changes.

New release of the ospsuite.reportingengine R package

• Installation and new features: see here
• Documentation: see here