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6.0.4

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@susannasiebert susannasiebert released this 05 Jan 17:13
· 322 commits to master since this release
v6.0.4
e46803d

What's Changed

This is a bugfix release. It fixes the following problem(s):

  • Fix a couple of FASTA creation bugs. by @susannasiebert in #1352

    • Some frameshift mutations have no VEP-predicted downstream tail. This may occur when the transcript amino acid sequence contains a U (unknown). If this happens while the somatic mutation occurs after the U, the mutant sequence extracted by pVACseq will be empty, which results in downstream errors. These types of variants are now skipped since they don’t produce any novel neoantigen candidates.

    • In the process of evaluating the issue above, another bug was discovered. When restarting a run that had failed during the fasta creation step the restart would no longer incorporate proximal variants into the predicted wildtypes and mutant sequences. This issue has been fixed.

Full Changelog: v6.0.3...v6.0.4

Contributors

susannasiebert
Assets 2
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