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CORGIAS Network

github-actions[bot] edited this page Jul 30, 2026 · 5 revisions

CORGIAS Network

The CORGIAS Network displays phylogenetically informed associations among SAR11 orthogroups, calculated with CORGIAS from the current 542-genome orthogroup matrix and rooted SAR11_165 IQ-TREE 2 phylogeny.

The network contains 17,853 significant associations among 2,982 OGs after multiple-testing correction: 17,631 positive associations and 222 negative associations. Node labels and functional annotations are read from the current og_suggest.tsv summary.

Nodes represent orthogroups and are colored by COG functional category. Edges summarize statistically supported relationships:

  • Red indicates a positive correlation or co-occurrence.
  • Blue indicates a negative correlation or anti-occurrence.
  • Edge width represents -log10(q-value); thicker edges indicate stronger statistical support.

Extract A Local Network

  1. Enter a center OG ID such as OG0001059.
  2. Set Depth to control how many network steps are included.
  3. Set the Significance (-log10 q) threshold to exclude weaker edges.
  4. Set Max nodes to limit the rendered network.
  5. Press Show network.

The status line reports the total, selected, and visualized node counts. If the network is slow or visually crowded, reduce its depth, increase the significance threshold, or lower the maximum node count.

Browse Significant Associations

The CORGIAS result table lists all 17,853 significant associations and is ordered by ascending q-value by default. Search OG IDs or representative COG and KO annotations, or sort the table by association direction, p-value, q-value, or -log10(q-value). Select an OG ID to open its integrated information page. The complete table can also be downloaded as TSV.

Explore And Export

Hover over network elements to inspect orthogroup and annotation information. The pointer cursor identifies clickable nodes; select one to open its OG Information Viewer in a separate tab. Use Export PNG for a figure or Export JSON for the currently extracted network.

CORGIAS relationships are phylogenetically informed statistical associations and should not by themselves be interpreted as direct physical interactions or evidence of a shared operon. Use Neighboring Genes or the Neighboring Network to examine genome context.

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