solubility gain per charge

[jiameng04]

Hello everyone, I would like to ask a question, that is, what does this mean in the title, and don't we have to consider this parameter when building the model?thanks

[AndreDlm]

Dear @jiameng04,
The solubility gain per charge is a factor that determines by how much the solubility of a non-neutral compound changes when the pH of the medium is changed.

You can display the solubility-pH profile by clicking on Show Graph next to the solubility gain per charge:

Decreasing the solubility gain per charge generally reduces the effect of altered pH on the drug's solubility (e.g., if solubility gain per charge is 1, there is no effect of pH on the drug's solubility and its solubility is constant across the entire pH range), and increasing the solubility gain per charge enhances the effect.

If you have (aqueous) solubility data measured at different pH, you could use these data to fit the solubility gain per charge.
@Paul-Vrnkn is currently developing a tool for this that will be shared in a few weeks at the latest.

[jiameng04]

我明白了，十分感谢您的回复

[AndreDlm]

You're welcome!

[Yuri05]

Dear @jiameng04, please use English in the forum. Thank you.

[jiameng04]

Thanks for the reminder, as I didn't see the requirement to use English, sorry about that!