Help needed to modify Caco2 scaling equation parameters m and b

[Damian37-2]

Dear community,

I am looking for some help relatd to scaling of Caco2 data in the OPS software. For some oral simulation runs with my compound, I want to implement Caco2 data from literature and scale this to effective permeability. I saw that this can be directly done in PKsim/MoBi as the following formula is implemented in the software: PARAM_P_int (10^(m*log10(P_int_InVitro)+b)).

Unfortuantly, I seem not to be able to find the m and b parameters from this equation in the software. I hope anyone can help to show me where I can find and modify these parameters to scale my Caco2 data directly in the software (I am working in version 12.3).

Many thanks in advance.

With regards,

Damian

[Yuri05]

You can find the parameters here (make sure to activate the Advanced parameters display mode):

[Damian37-2]

Dear Yuri,

Many thanks for your quick response and providing me with the solution!

Have a good day!

With regards,

Damian