Scaling of Caco2 data to intestinal permeability: how to implement this correct in PKsim

[Damian37-2]

Dear community,

I am working on a PBK model in PKsim and want to inform the intestinal absorption (specific intestinal permeability). From my understanding, but please correct me if I am wrong, is the specific intestinal permeability is scaled to the intestinal permeability based on the following formula in PKsim: Pint = 10^(m * log10(P_int_InVitro) + b).

The P_int_InVitro can be calculated in PKsim based on physicochemical properties or can be manually added based on f.e. Caco-2 data.

My question is as follow: Since I only have Caco-2 data from literature and no other compounds were tested in the published study to make any corrections, would it be possible to inform the m and b parameters in the Pint formula based on the Sun et al. 2002 (Pharm Res 19:1400-1416) paper using their equation for all drug types to correct the Caco-2 data in PKsim for the scaling to Pint/intestinal permeability.

Many thanks for your help/input in advance.

With regards,

Damian

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