MoBi open error

[Bunny-Tutu]

Hello OSP team,

I am encountering a launch failure error when opening the MoBi software from the Open Systems Pharmacology Suite. The full error details are shown as below:

My current installed versions are MoBi 12.3 and the full OSP Suite 12.3.263. The software crashes immediately when attempting to load the calculation methods repository during the startup process, which blocks all further operations. I have tried running the program as administrator multiple times, but the problem remains unsolved. Could you please help me check the root cause of this method missing exception, and provide the official troubleshooting steps or a patch to resolve this compatibility issue?

Thank you very much for your guidance.

Best regards,

Bunny

[github-actions[bot]]

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[rwmcintosh]

Find the MoBi install folder and look for the OSPSuite.Core.dll file.
Then right click on the file, select properties, then the details tab

Find the file version. In my example, it's 12.2, but yours should be a 12.3 number.

[Bunny-Tutu]

Thank you very much for your help.

[rwmcintosh]

Something is wrong with the System.ValueTuple.dll maybe.

In the MoBi folder open a PowerShell and run these, then post the result of both

Check for local version

Get-Item "System.ValueTuple.dll" | ForEach-Object { "{0} bytes  {1}" -f $_.Length, (Get-FileHash $_ -Algorithm SHA256).Hash }

Check for GAC version

Get-ChildItem "C:\Windows\Microsoft.NET\assembly\GAC_MSIL\System.ValueTuple" -Recurse -Filter *.dll | ForEach-Object { "{0}  {1} bytes" -f $_.FullName, $_.Length }

[Bunny-Tutu]

Many thanks！

[rwmcintosh]

Try this next

In the MoBi folder find MoBi.exe.config. It's an XML file and it should have something like this

<assemblyIdentity name="System.ValueTuple" publicKeyToken="cc7b13ffcd2ddd51" culture="neutral" />
<bindingRedirect oldVersion="0.0.0.0-4.0.3.0" newVersion="4.0.3.0" />

Where it says newVersion="4.0.3.0" change to newVersion="4.0.0.0" . Only change the System.ValueTuple entry. There might be others with similar content

Then if that works, you could do me a favor by running this command so I can see how the version got installed in the GAC?

Get-ChildItem "C:\Windows\Microsoft.NET\assembly\GAC_MSIL\System.ValueTuple" -Recurse -Filter *.dll | ForEach-Object { "{0}`n  created {1}  product '{2}'" -f $_.FullName, $_.CreationTime, $_.VersionInfo.ProductName }

[Bunny-Tutu]

This method works perfectly, thank you so much! Now MoBi can be opened normally, and here is the screenshot you need.