Inquiry Regarding Atorvastatin PBPK Model Files

[arjunkmadathil]

Hi all,

Our group is currently working on PBPK modelling of statins and related drug classes, including applications to drug–drug interaction evaluations.

We came across the Open Systems Pharmacology model repository GitHub folder: https://github.com/Open-Systems-Pharmacology/Atorvastatin-Model

The repository and associated materials appear highly relevant to our work. However, we have not been able to locate the actual model files for atorvastatin/atorvastatin acid that could be opened and explored within the OSP Suite.

Could anyone please advise whether these model files are publicly available and, if so, where we can access or download them? We would greatly appreciate your guidance.

Thank you very much for your help.

Best regards,
Dr. Arjun Kolappurath Madathil
Department of Pharmacy and Pharmaceutical Sciences
National University of Singapore
Singapore

[Ricardo-DO]

Hi Arjun,

The model file is a json (snapshot) file, not a .pksim5 file.
You need to donwload the json file from here

Then open PKSim and open the Load from snapshot option

Select the file and click on "Start import" and you get the PKSim model.

I hope that helps.

Ricardo