I would like to submit a OSP model snapshot

[OliversLab]

Dear all,

I would like to contribute and deposit the first version of our Cabozantinib PBPK model. Would this be possible?

name of your model: Cabozantinib

short description of the model repository:

Cabozantinib PBPK

Within this repository we share whole body PBPK model of the TKI Cabozantinib with enterohepatic recirculation (EHC) and drug-drug-interaction (DDI) via CYP3A4 inducer. The model was developed using available pharmacokinetic studies. The model describes the EHC and the DDIs with Rifampin as CYP3A4 inducer.

For a detailed documentation of model development, quantitative model evaluation and sensitivity analysis, please refer to [1].

License

The model code is distributed under the [GPLv2 License]

References

[1] Gerner, B.; Scherf-Clavel, O. Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug-Drug Interaction with Rifampin and Liver Impairment. Pharmaceutics 2021, XX, XXX.

repository topics: pbpk, ddi

Thank you very much,
best regards,
Oliver

[Yuri05]

@OliversLab I have created new repository Cabozantinib-Model
You can add your files as described in CREATING_MODEL_REPOSITORY
Thanks for your contribution.

[OliversLab]

Thank you so much.
Have a nice weekend.
Oliver