drug-drug interaction by protein displacement in plasma in PK-Sim

[mmalsmadi]

Hello

Does PK-Sim allow for accounting for drug-drug interaction via displacement of plasma protein binding?
What settings should be done to account for such phenomena in PK-Sim?

[StephanSchaller]

Hi @mmalsmadi, this is not a functionality that PK-Sim provides by default but can be achieved by customization through MoBi.
Similar to this issue, you will have to change fu to be formula-dependent and integrate the DDI therein.

[mmalsmadi]

Many thanks, I will try it and keep you posted Get Outlook for Android<https://aka.ms/AAb9ysg>

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________________________________ From: esqlabs GmbH ***@***.***> Sent: Tuesday, June 8, 2021 2:19:55 PM To: Open-Systems-Pharmacology/Forum ***@***.***> Cc: Mo'tasem Alsmadi ***@***.***>; Mention ***@***.***> Subject: Re: [Open-Systems-Pharmacology/Forum] drug-drug interaction by protein displacement in plasma in PK-Sim (#912) Hi @mmalsmadi<https://github.com/mmalsmadi>, this is not a functionality that PK-Sim provides by default but can be achieved by customization through MoBi. Similar to this issue<#907>, you will have to change fu to be formula-dependent and integrate the DDI therein. — You are receiving this because you were mentioned. Reply to this email directly, view it on GitHub<#912 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/AI6MN6TTPC6VDNXHUML7BE3TRX4FXANCNFSM46HQVTDA>.