I am a novice,I try to repeat the model in a document, which is made with PKSIM, but there are some parameters I can't find, and some units I can't convert. What should I do? help me.

[Achineseman]

[nasirkalam]

Dear major plasma protein binding selection is available at 1st tab of compound. In table 4 values of CLint of CYP enzyme is calculated by retrograde model of hepatic clearance. An additional 17.6% hepatic clearance was assigned in 2nd tab of compound. Then select both of these clearance mechanisms while running simulations. Fractional changes in liver cirrhosis were made by multiplying this fractions with blood flow in individual file.

…

On Fri, 30 Jul 2021, 21:45 Achineseman, ***@***.***> wrote: [image: 屏幕截图 2021-07-31 003516] <https://user-images.githubusercontent.com/81560924/127684847-f5ac90dc-8b4d-4e49-a338-a9b4efd22812.png> [image: 屏幕截图 2021-07-31 003700] <https://user-images.githubusercontent.com/81560924/127684857-2e68e0be-08a8-42af-9c1d-a7eaa86369f1.png> [image: 屏幕截图 2021-07-31 003744] <https://user-images.githubusercontent.com/81560924/127684868-2c4dac6b-1121-48ba-8034-9378fa39ca91.png> [image: 屏幕截图 2021-07-31 004352] <https://user-images.githubusercontent.com/81560924/127685258-5e3b56ce-dadc-4e7d-9bef-78fe9a71e376.png> [image: 屏幕截图 2021-07-31 004432] <https://user-images.githubusercontent.com/81560924/127685269-7946c4e6-41df-4ac0-a6d5-c45e65943c94.png> — You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub <#944>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/ALKRQEKSGD3WDSOCXCLZ3T3T2LJKNANCNFSM5BI3R6BQ> .