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rdmorin edited this page Jun 21, 2024 · 1 revision

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1 FL genes

66 total

Gene Tier First FL evidence Other entities
ACTB 1, aSHM [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
ARID1A 1 Study Page[@krysiakRecurrentSomaticMutations2017b] [@wienandGenomicAnalysesFlowsorted2019b; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @loveGeneticLandscapeMutations2012]
ATP6AP1 1 Study Page[@okosunRecurrentMTORC1activatingRRAGC2016a]
ATP6V1B2 1 Study Page[@okosunRecurrentMTORC1activatingRRAGC2016a]
B2M 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]
BCL2 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@tanakaFrequentIncidenceSomatic1992; @burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]
BCL6 1, aSHM [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BCL7A 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@grandeGenomewideDiscoverySomatic2019; @arthurGenomewideDiscoverySomatic2018; @reichelFlowSortingExome2015a]
BIRC6 1 [@sarkozyMutationalLandscapeGray2021a; @reddyGeneticFunctionalDrivers2017]
BTG1 1, aSHM [@sarkozyMutationalLandscapeGray2021a; @morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b]
BTG2 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@loveGeneticLandscapeMutations2012]
BTK 1 Study Page[@krysiakRecurrentSomaticMutations2017b] [@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@lenzOncogenicCARD11Mutations2008; @paneaWholeGenomeLandscape2019; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]
CCND3 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]
CD83 1, aSHM Study Page[@russler-germainMutationsAssociatedProgression2023b] [@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013]
CREBBP 1 Study Page[@pasqualucciInactivatingMutationsAcetyltransferase2011a] [@dunsCharacterizationDLBCLPMBL2021b; @parryWholeExomeSequencing2013; @loveGeneticLandscapeMutations2012]
CTSS 1 Study Page[@barariaCathepsinAlterationsInduce2020c]
DTX1 1, aSHM [@schmitzGeneticsPathogenesisDiffuse2018a; @gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c]
EBF1 1, aSHM [@reichelFlowSortingExome2015a; @bohleRoleEarlyBcell2013; @thomasGeneticSubgroupsInform2023]
EEF1A1 1 Study Page[@hubschmannMutationalMechanismsShaping2021b] [@reichelFlowSortingExome2015a]
EP300 1 Study Page[@pasqualucciInactivatingMutationsAcetyltransferase2011a] [@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]
EZH2 1 Study Page[@morinSomaticMutationsAltering2010a] [@mottokIntegrativeGenomicAnalysis2019b; @loveGeneticLandscapeMutations2012]
FAS 1 [@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]
FOXO1 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]
GNA13 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]
GNAI2 1 [@morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]
HIST1H1B 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@paneaWholeGenomeLandscape2019]
HIST1H1D 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017]
HIST1H1E 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H2AC 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@morinMutationalStructuralAnalysis2013]
HIST1H2AG 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@morinMutationalStructuralAnalysis2013; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]
HIST1H2AM 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019]
HIST1H2BC 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@lohrDiscoveryPrioritizationSomatic2012a; @mottokIntegrativeGenomicAnalysis2019b]
HIST1H2BD 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b]
HIST1H2BG 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b]
HIST1H3B 1, aSHM [@reichelFlowSortingExome2015a; @lohrDiscoveryPrioritizationSomatic2012a]
HIST1H3G 1, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b]
HVCN1 1 Study Page[@krysiakRecurrentSomaticMutations2017b]
IRF4 1, aSHM [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019b]
IRF8 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@paneaWholeGenomeLandscape2019; @mottokIntegrativeGenomicAnalysis2019b]
ITPKB 1, aSHM [@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]
KLF2 1, aSHM [@jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011; @deschGenotypingCirculatingTumor2020]
KLHL6 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@paneaWholeGenomeLandscape2019; @ganapathiGeneticLandscapeDural2016]
KMT2D 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019; @deschGenotypingCirculatingTumor2020]
LTB 1, aSHM [@paneaWholeGenomeLandscape2019; @deschGenotypingCirculatingTumor2020; @chapuyMolecularSubtypesDiffuse2018b]
MAP2K1 1 Study Page[@louissaintPediatrictypeNodalFollicular2016a] [@shinBRAFV600EMAP2K12015]
MEF2B 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@beaLandscapeSomaticMutations2013]
MEF2C 1, aSHM [@arthurGenomewideDiscoverySomatic2018]
PCLO 1 [@lohrDiscoveryPrioritizationSomatic2012a]
PIM1 1, aSHM [@dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a; @burkhardtClinicalRelevanceMolecular2022b]
POU2AF1 1 Study Page[@krysiakRecurrentSomaticMutations2017b]
POU2F2 1 Study Page[@krysiakRecurrentSomaticMutations2017b] [@lohrDiscoveryPrioritizationSomatic2012a]
PTPRD 1 [@spinaGeneticsNodalMarginal2016b]
RRAGC 1 [@okosunRecurrentMTORC1activatingRRAGC2016a]
S1PR2 1, aSHM [@muppidiLossSignalingGa132014b; @morinFrequentMutationHistonemodifying2011]
SGK1 1, aSHM Study Page[@morinFrequentMutationHistonemodifying2011] [@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4 1 Study Page[@krysiakRecurrentSomaticMutations2017b] [@richterRecurrentMutationID32012a; @nadeuGenomicEpigenomicInsights2020b; @lohrDiscoveryPrioritizationSomatic2012a]
SOCS1 1, aSHM [@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
STAT6 1 Study Page[@yildizActivatingSTAT6Mutations2015c] [@ritzRecurrentMutationsSTAT62009a]
TBL1XR1 1 [@lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c]
TMSB4X 1, aSHM [@albuquerqueEnhancingKnowledgeDiscovery2017a]
TNFAIP3 1 [@rossiAlterationBIRC3Multiple2011a; @compagnoMutationsMultipleGenes2009a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14 1 Study Page[@cheungAcquiredTNFRSF14Mutations2010a] [@spinaGeneticsNodalMarginal2016b; @morinFrequentMutationHistonemodifying2011]
TP53 1 Study Page[@morinFrequentMutationHistonemodifying2011] [@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004; @lohrDiscoveryPrioritizationSomatic2012a]
VMA21 1 Study Page[@hubschmannMutationalMechanismsShaping2021b]

Tier 2 FL genes

50 total

Gene Tier First FL evidence Other entities
ABL2 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
ACTG1 2, aSHM Study Page[@hubschmannMutationalMechanismsShaping2021b] [@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]
ATP6V1A 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
BCL10 2 Study Page[@russler-germainMutationsAssociatedProgression2023b] [@spinaGeneticsNodalMarginal2016b; @morinFrequentMutationHistonemodifying2011]
CD70 2 Study Page[@russler-germainMutationsAssociatedProgression2023b] [@morinFrequentMutationHistonemodifying2011]
CD79B 2 [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CDC42BPB 2 Study Page[@hubschmannMutationalMechanismsShaping2021b] [@spinaGeneticsNodalMarginal2016b]
CILP 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
CPNE8 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
CXCR4 2, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019; @khodabakhshiRecurrentTargetsAberrant2012]
CYP2A6 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
DDX3X 2 [@schmitzGeneticsPathogenesisDiffuse2018a; @mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]
DHX15 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
DUSP2 2, aSHM [@dunsCharacterizationDLBCLPMBL2021b; @lohrDiscoveryPrioritizationSomatic2012a]
EGR1 2 Study Page[@krysiakRecurrentSomaticMutations2017b] [@rossiCodingGenomeSplenic2012c; @reichelFlowSortingExome2015a]
FZR1 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
GBP7 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
GRM6 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
HIST1H2BM 2, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b]
HIST1H3I 2, aSHM Study Page[@krysiakRecurrentSomaticMutations2017b] [@paneaWholeGenomeLandscape2019]
HLA-B 2 [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
HNRNPD 2
IGLL5 2, aSHM Study Page[@russler-germainMutationsAssociatedProgression2023b] [@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
JUP 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
KIR3DL1 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
LAPTM5 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
MAGEC1 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
MAP7D1 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
MGEA5 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
MKI67 2 Study Page[@russler-germainMutationsAssociatedProgression2023b] [@schmitzBurkittLymphomaPathogenesis2012]
MYC 2, aSHM [@pasqualucciHypermutationMultipleProtooncogenes2001a; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b]
MYCBP2 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
MYD88 2 [@yanBCRTLRSignaling2012a; @ngoOncogenicallyActiveMYD882011a]
NFKBIA 2 Study Page[@russler-germainMutationsAssociatedProgression2023b] [@wienandGenomicAnalysesFlowsorted2019b; @lakeMutationsNFKBIAEncoding2009]
OR8H2 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
P2RY8 2 [@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]
PDS5B 2 Study Page[@hubschmannMutationalMechanismsShaping2021b] [@morinMutationalStructuralAnalysis2013]
PPP4C 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
PRKDC 2 Study Page[@hubschmannMutationalMechanismsShaping2021b] [@schmitzGeneticsPathogenesisDiffuse2018a]
PZP 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
RBM6 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
SESN1 2 Study Page[@oricchioGeneticEpigeneticInactivation2017b]
SHROOM3 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
SRRM2 2 Study Page[@russler-germainMutationsAssociatedProgression2023b] [@morinMutationalStructuralAnalysis2013]
STAB2 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
TMEM30A 2 Study Page[@morinFrequentMutationHistonemodifying2011]
TPP1 2 Study Page[@hubschmannMutationalMechanismsShaping2021b]
XIRP2 2 Study Page[@russler-germainMutationsAssociatedProgression2023b]
ZC3H12A 2 [@arthurGenomewideDiscoverySomatic2018]
ZNF608 2 Study Page[@krysiakRecurrentSomaticMutations2017b] [@zhangGeneticHeterogeneityDiffuse2013]

References

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