Known Molecular Discoveries

Known molecular discoveries — public review ledger

Status: LOOK LIVE — 2026-08-25 · PDB id Claim LIVE · occupancy DARK
Program: Study 14 — Protein lattice · Study 15 — Skala DFT shear · Language-games study board

Surface	URL	Grade
Catalog GET	https://affine.earth/language-game/discoveries/catalog.json	LIVE · credentials: omit · no visitor data
IDE	https://affine.earth/language-game/ide.html#discovery-review	Template opens a fetched record
Look walks	https://affine.earth/language-game/#researcher	GET links only. No auto-POST.
Claim	#pdb-holdings 4HHB / 2HYY	LIVE on presented pdb_id · occupancy / residue / pocket stay DARK

The win is the verified bond, not custody of a fold and not a true/false “discovery” bit.

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For every reader — one paragraph

A named public discovery here is a fetched industry record — a PDB accession in the hosted holdings, a PubChem CID, a ChEMBL id, a DailyMed SPL — walked Look → Claim → Build → Share. The cell serves the holdings index (N=258616) and a handful of fact sheets whose fields came from those fetches (4HHB, aspirin CID 2244 / CHEMBL25, DailyMed insulin human). Claim on a presented 4-char pdb_id is LIVE. Occupancy / residue / pocket stay DARK. The meaning of a WIN is holdings membership of that id, not a dock and not a cookbook.

Instructions means cited public facts and links — INN, indication on the label, PDB / PubChem / ChEMBL / DailyMed id, manufacture class (recombinant / chemical / extracted) from FDA / EMA / label / PDB. It does not mean a synthesis cookbook. C-007: no pathogen enhancement, no military, no unpublished manufacture steps.

Using something that is not accurate (because it shears) may not be useless — it may be dangerous. Skala / float MD / AlphaFold are the adversary on Study 14 / 15, not our method.

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Measured catalogs — 2026-08-24 (VERIFIED vs REPORTED)

Catalog	Number	Grade	Source · fetched
RCSB PDB current holdings	258616 entry ids	VERIFIED	GET https://data.rcsb.org/rest/v1/holdings/current/entry_ids HTTP 200 · 2026-08-24T17:13:23Z · example id 1IWB
RCSB search total_count (experimental)	258222	VERIFIED	POST https://search.rcsb.org/rcsbsearch/v2/query HTTP 200 · example id 100D
Hosted index index_n	258616	VERIFIED (copy of the holdings fetch)	/language-game/discoveries/catalog.json
ChEMBL distinct compounds	2921148	VERIFIED	status.json + molecule.json page_meta.total_count · ChEMBL_37 · 2026-05-01 · status UP
ChEMBL compound records	3824604	VERIFIED	same status.json
DailyMed SPL count drug_name=aspirin	1077	VERIFIED	spls.json?drug_name=aspirin HTTP 200
DailyMed SPL count drug_name=insulin human	22	VERIFIED	spls.json?drug_name=insulin%20human HTTP 200
PubChem compound universe	millions of CIDs	REPORTED (PUG listkey count HTTP 500 this hour)	Example VERIFIED: CID 2244 Aspirin C9H8O4

Do not collapse 258616 and 258222 into one invented number. Holdings is the index we host. Search total_count is a second instrument on a filtered query.

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One example record (fetched, not invented)

4HHB — RCSB · REST HTTP 200

Field	Value	Came from
id	4HHB	holdings + core entry
name	THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION	struct.title
method	X-RAY DIFFRACTION	exptl[0].method
polymer_entity_count	2	rcsb_entry_info
deposit_date	1984-03-07	rcsb_accession_info
manufacture_class	none on this row	PDB is a structure archive, not a marketed-product label

Aspirin — PubChem CID 2244 · ChEMBL CHEMBL25 · DailyMed setid ee8d0961-7572-471f-8c96-b4c0bd354de2

Field	Value	Came from
INN	aspirin	PubChem Title / ChEMBL pref_name
formula	C9H8O4	PubChem
IUPACName	2-acetyloxybenzoic acid	PubChem
molecule_type	Small molecule	ChEMBL_37
first_approval	1950	ChEMBL
ATC	B01AC06 · N02BA01 · N02BA51 · A01AD05	ChEMBL
manufacture_class	chemical	ChEMBL small molecule + DailyMed tablet SPL. Not a synthesis recipe.

Insulin human — DailyMed setid e245e0c5-b2d6-418b-baa4-1c3324292885 (HUMULIN 70/30, Eli Lilly)

Field	Value	Came from
INN	insulin human	DailyMed title
manufacture_class	recombinant	Named product HUMULIN on the FDA/DailyMed listing. GET the SPL for the label text. Not a cookbook.

No IC50 is written on any row. If a number was not in the fetch, it is absent.

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How the four acts land here

Act	Researcher does	This surface
1 LOOK	GET the catalog. No identity.	catalog.json · #researcher
2 CLAIM	POST a presented PDB id + source+role	LIVE on #pdb-holdings. Occupancy / pocket stay DARK. Do not treat health dose as a pocket.
3 BUILD	Open the record in the IDE that exists	ide.html#discovery-review
4 SHARE	GET view that names source	this page · catalog examples[]

feeds_catalog / corpus_bonds / umc_* already name transports. No new MCP tool.

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What this page does not do

• Does not invent thousands of fake discovery rows
• Does not write a synthesis cookbook
• Does not land ProteinManifold.evaluateDocking or an O(1) dock
• Does not claim folding, docking, or thermochemistry is solved
• Does not call Skala / float MD / AlphaFold useless
• Does not POST occupancy, residue, or pocket integers

Status: LOOK LIVE — hosted index N=258616. PDB id Claim LIVE. Occupancy DARK. Family ledger: Known discoveries. Play: Study 14 · IDE #pdb-holdings.

Generated-candidate hashes (not this catalog): protein-material-aggregates.json — Look only. Generated rows without a PDB/ICD/InChI/COD key are not playable.